张立伟，男，1963年11月生，教授，博士生导师，农工民主党党员。山西省333创新人才，山西省学术技术带头人，山西省三晋英才-拔尖骨干人才。国家林业和草原局“连翘资源培育及利用研究科技创新联盟” 副理事长，山西省药学会常务理事、世中联中药鉴定专业委员会理事、中华中医药学会对外交流与合作分会委员会委员、世中联中药保健品专业委员会委员。受聘为山西省教委联系的高级专家。1984年7月毕业于山西大学化学系，同年在晋中师专化学系任教；1990年7月获山西大学理学硕士学位；2002年7月获山西大学理学博士学位。2008年赴日本神户药科大学进行合作研究。

研究领域：主要从事中药物质基础及中药资源开发研究。
历年主持完成科技部国家科技支撑、中药新药创制课题、国家工信部、国家发改委、省自然科学基金、省科技攻关、省留学基金、太原市明星项目，以及企业合作研究项目等40余项。获得山西省自然科学二等奖1项、山西省科技进步二等奖1项，技术转让中药新药成果1项，中药专利技术成果5项。在国内外学术刊物上发表有关学术论文150余篇，制订各类中药材标准5个，获得国家发明专利30余件。

近五年主要成果：

1. Huan-Huan Xue , Jing-Jing Li , Shi-Fei Li , Jing Guo , Rui-Ping Yan , Ting-Gui Chen , Xiang-Hua Shi , Jin-Dong Wang and Li-Wei Zhang*. Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways. Int. J. Mol. Sci. 2023, 24, 2238

2. Lei Wu , Xiang Jin , Canwen Zheng , Fengjing Ma , Xue Zhang , Pengfei Gao , Jianhua Gao * and Liwei Zhang *.  Bidirectional Effects of Mao Jian Green Tea and Its Flavonoid Glycosides on Gastrointestinal Motility，Foods， 2023, 12, 854

3. Lei Wu, Liming Gao , Xiang Jin , Zhikang Chen , Xutong Qiao , Xiting Cui , Jianhua Gao , and Liwei Zhang *.  Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway. Foods， 2023, 12, 1101.

4. Tao Wang, YuanBo Zhang, BaiFang Wang, JianKai Tang, XueJian Guo, ShiFei Li, LingHao Qin and Liwei Zhang *. Screening of Antimicrobial Ingredients in Forsythia Leaves Using Target Constituent Knockout/Knock-in Strategy and Evaluation of the Combination Effects with Antibiotics，Natural Product Communications，2023，18(3): 1-7.

5. Shifei Li* , Xiuyi Wang, Yuqin Yang, Xingkang Wu and Liwei Zhang* . Discovering the Mechanisms of Oleodaphnone as a Potential HIV Latency-Reversing Agent by Transcriptome Profiling，International Journal of Molecular Sciences，Int. J. Mol. Sci. 2023, 24, 7357

6. Jing Guo , Wen-Rui Yan , Jian-Kai Tang , Xiang Jin , Huan-Huan Xue , Tao Wang , Li-Wei Zhang * , Qian-Yun Sun **, Zhan-Xue Liang. Dietary phillygenin supplementation ameliorates aflatoxin B1-induced oxidative stress, inflammation, and apoptosis in chicken liver，Ecotoxicology and Environmental Safety，2022，236：113481.

7. Tao Wang, Xu-Jiong Li *, Ling-Hao Qin , Xue Liang, Huan-Huan Xue, Jing Guo, Shi-Fei Li and Li-Wei Zhang*，Better detoxifying effect of ripe forsythiae fructus over green forsythiae fructus and the potential mechanisms involving bile acids metabolism and gut microbiota，Front. Pharmacol., 2022，13: 987695.

8. Jing Guo，Jian-Kai Tang，Bai-Fang Wang，Wen-Rui Yan，Ting Li，Xue-Jian Guo，Lei Zhang，Tao Wang，Qian-Yun Sun，Li-Wei Zhang*. Phillygenin from Forsythia suspensa leaves exhibits analgesic potential and anti-inflammatory activity in carrageenan-induced paw edema in mice，J. Food. Biochem. 2022，00: e14460.

9. Lingzhi Wang, Wenrui Yan, Yurun Tian, Huanhuan Xue, Jiankai Tang and Liwei Zhang*. Self‐Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation. Pharmaceutics 2020, 12, 130.

10. Yanhua Tian， Huizhi Du，Xiaohuan Qing， Liwei Zhang*. Efects of picking time and drying methods on contents of eight lavonoids and antioxidant activity of leaves of Diospyros lotus L.，Journal of Food Measurement and Characterization，2020，14(3)：1461-1469.

11. Shifei Li *, Ting Li, Yufang Jin Xuemei Qin, Junsheng Tian* and Liwei Zhang*. Antidepressant-Like Effects of Coumaroylspermidine Extract From Safflower Injection Residues，Frontiers in Pharmacology，2020，11,  713.

联系方式：
地址：太原市坞城路92号
单位：山西大学分子科学研究所
邮编：030006
电话：0351-7018113
传真：0351-7018113
eMail: lwzhang@sxu.edu.cn