王宏飞，山西大学分子科学研究所博士生导师，二级教授。1996年毕业于中国南京大学获得理学博士学位，2001年毕业于日本立教大学获得理学博士学位。2001年至2003年，在日本理化学研究所基因科学研究中心从事博士后研究。2003年至2009年，在日本理化学研究所生命分子系统研究领域任特别研究员。作为实验负责人，具有二十多年大型同步辐射光源SPring-8、日本光子工厂和上海光源的使用经验。2012年入选山西省引进海外高层次人才计划。2013年入选山西省高等院校131领军人才工程，2014年入选山西省学术技术带头人。2015年入选中国生物医学光子学专业委员会委员，2018年入选中国生物物理化学专业委员会委员。2022年获得山西省科技合作二等奖（第一完成人）。

研究兴趣和领域：化学生物学，生物无机化学，生物物理。

近期发表论文:

1 Wenming Wang, Hongfang Xi, Dan Fu, Danyang Ma, Wenjun Gong, Yaqin Zhao, Xiaomei Li, Lijie Wu, Yu Guo, Guanghua Zhao, Hongfei Wang. Growth Process of Fe-O Nanoclusters with Different Sizes Biosynthesized by Protein Nanocages. J Am Chem Soc. 2024, 146, 11657-11668.

2 Wenjun Gong, Tao Wu, Yuhua Liu, Shuxiang Jiao, Wenming Wang, Wenjun Yan, Yanqiu Li, Yanhong Liu, Yun Zhang, Hongfei Wang. Insight into the photodynamic mechanism and protein binding of a nitrosyl iron-sulfur [Fe2S2(NO)4]2- cluster. Spectrochim Acta A Mol Biomol Spectrosc. 2024, 320, 124603.

3 Jia Shi, Leilei Xie, Wenjun Gong, Hehe Bai, Wenming Wang, Ai Wang, Wei Cao, Hongbo Tong, Hongfei Wang. Insight into the anti-proliferation activity and photoinduced NO release of four nitrosylruthenium isomeric complexes and their HSA complex adducts. Metallomics. 2024, 16(2), mfae005.

4 Hehe Bai, Wenjun Gong, Yating Pang, Chaoyang Shi, Zhigang Zhang, Lili Guo, Yafeng Li, Lili Guo, Wenming Wang, Hongfei Wang. Synthesis, cytotoxicity, and biomacromolecule binding: Three isomers of nitrosylruthenium complexes with bidentate bioactive molecules as co-ligands. Int J Biol Macromol. 2023, 243, 243125009.

5 Wenming Wang, Yuan Wang, Hongfang Xi, Zidan Song, Wenlong Zhang, Leilei Xie, Danyang Ma, Nan Qin, and Hongfei Wang. Extension Peptide of Plant Ferritin from Setaria italica Presents a Novel Fold. J. Agric. Food Chem. 2023, 71, 934-943.

6 Hehe Bai, Jia Shi, Qingyu Guo, Wenming Wang, Zhigang Zhang, Yafeng Li, Manohar Vennampalli, Xuan Zhao, Hongfei Wang. Spectroscopy, Structure, Biomacromolecular Interactions, and Antiproliferation Activity of a Fe(II) Complex With DPA-Bpy as Pentadentate Ligand. Front Chem. 2022, 10, 888693.

7 Wenming Wang, Xiaojia Liu, Yajie Wang, Yuan Wang, Dan Fu, Hongfang Xi, Yi Zhao, Hongfei Wang. Distinct structural characteristics define a new subfamily of Mycoplasma ferritin. Chinese Chem Lett. 2022, 33(11): 4952-4955.

8 Leilei Xie, Hehe Bai, Luna Song, Chenyang Liu, Wenjun Gong, Wenming Wang, Xuan Zhao, Chie Takemoto, Hongfei Wang. Structural and Photodynamic Studies on Nitrosylruthenium -Complexed Serum Albumin as a Delivery System for Controlled NO Release, Inorg Chem. 2021, 60, 8826-8837.

9 Xiaorong Zhang, Yu Liu, Bowen Zheng , Jiachen Zang, Chenyan Lv, Tuo Zhang, Hongfei Wang, Guanghua Zhao. Protein interface redesign facilitates the transformation of nanocage building blocks to 1D and 2D nanomaterials. Nat Commun. 2021,12(1):4849.

10 Wenming Wang, Yao Zhang, Guanghua Zhao, Hongfei Wang. Ferritin with Atypical Ferroxidase Centers Takes B-Channels as the Pathway for Fe2+ Uptake from Mycoplasma, Inorg Chem. 2021, 60, 7207-7216.

11 Luna Song, Hehe Bai, Chenyang Liu, Wenjun Gong, Ai Wang, Li Wang, Yi Zhao, Xuan Zhao, Hongfei Wang. Synthesis, Biomacromolecular Interactions, Photodynamic NO Releasing and Cellular Imaging of Two [RuCl(qn)(Lbpy)(NO)]X Complexes, Molecules 2021, 26, 2545.

12 Xue Bai, Yantao Zhu, Hongfei Wang, Jiangang Li, Zhigang Zhang. Triphenylphosphonium -functionalized nanocomposites as carriers of a platinum diimine complex for photodynamic therapy, Photodiagnosis Photodyn Ther. 2021, 34, 102223.

13 Zhifan Liu, Hongfei Wang, Zhigang Zhang, A valproic acid-modified platinum diimine complex as potential photosensitizer for photodynamic therapy, J Inorg Biochem. 2021, 222, 111508.

14 Xiaodong Cui, Ke Wang, Tingfen Wang, Jiao Li, Chen Li, Wenming Wang, Hongfei Wang, Zhuanhua Wang. Crystal Structure Analysis of Cationic Peroxidase from Proso Millet and Identification of Its Phosphatase Active Sites, J Agric Food Chem. 2021, 69(22):6251-6259.

15 Qi Jing, Lifang Liu, Yu Zhang, Leilei Xie, Luna Song, Wenming Wang, Yanhong Liu, Xuan Zhao, Hongfei Wang. Structure, photodynamic reaction and DNA photocleavage properties of a nitrosyl iron-sulfur cluster (Me4N)2[Fe2S2(NO)4]: A DFT calculation and experimental study, Spectrochim Acta A Mol Biomol Spectrosc. 2020,238,118401.

16 Luna Song, Leilei Xie, Liqun Xu, Qi Jing, Chenyang Liu, Xiaoli Xi, Wenming Wang, Yi Zhao, Xuan Zhao, Hongfei Wang. Syntheses, spectra, photoinduced nitric oxide release and interactions with biomacromolecules of three nitrosylruthenium complexes. Polyhedron 2020, 185, 114596.

17 Chunkai Gu, Hai Chen, Yingjie Wang, Tuo Zhang, Hongfei Wang, and Guanghua Zhao. Structural Insight into Binary Protein Metal–Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chem Eur J. 2020, 26, 3016-3021.

18 Xiaoyi Tan, Hai Chen, Chunkai Gu, Jiachen Zang, Tuo Zhang, Hongfei Wang, Guanghua Zhao. Converting histidine-induced 3D protein arrays in crystals into their 3D analogues in solution by metal coordination cross-linking. Commun Chem. 2020, 3, 151.

19 Wenming Wang, Lele Wang, Guobang Li, Guanghua Zhao, Xuan Zhao, Hongfei Wang. AB loop engineered ferritin nanocages for drug loading under benign experimental conditions. Chem Commun. 2019, 55, 12344-12347.

20 Wenming Wang, Yao Zhang, Lele Wang, Qi Jing, Xiaolu Wang, Xiaoli Xi, Xuan Zhao, Hongfei Wang. Molecular structure of thermostable and zinc-ion-binding r-class carbonic anhydrases. Biometals 2019, 32,317-328.

21 Wenming Wang, Fengmei Zhao, Yarui Zhao, Weiwei Pan, Pengcheng Cao, Lintao Wu , Zhijun Wang, Xuan Zhao, Yi Zhao, Hongfei Wang. Design, Synthesis, And Preliminary Bioactivity Evaluation Of 2,7-Substituted Carbazole Derivatives As Potent Autotaxin Inhibitors And Antitumor Agents. Anticancer Agents Med Chem. 2019, 2(19), 256-264.

22 Wenming Wang, Lele Wang, Hai Chen, Jiacen Zang, Xuan Zhao, Guanghua Zhao, Hongfei Wang. Selective Elimination of the Key Subunit Interfaces Facilitates Conversion of Native 24-mer Protein Nanocage into 8-mer Nanorings. J Am Chem Soc. 2018, 140, 14078-14081.

23 Kai Zhou, Jiacen Zang, Hai Chen, Wenming Wang, Hongfei Wang, Guaghua Zhao. On-Axis Alignment of Protein Nanocage Assemblies from 2D to 3D through the Aromatic Stacking Interactions of Amino Acid Residues. ACS Nano 2018, 12, 11323-11332.

24 Leilei Xie, Lifang Liu, Wenming Wang, Zhiou Ma, Liqun Xu, Xuan Zhao, Hongfei Wang. The Structures, Spectroscopic Properties, and Photodynamic Reactions of Three [RuCl(QN)NO]2 Complexes (HQN = 8-Hydroxyquinoline and Its Derivatives) as Potential NO-Donating Drugs. Bioinorg Chem Appl., 2018, 7029376, 1-9.

25 Wenming Wang, Yaqin Zhao, Hongfei Wang, Bingsheng Yang. Crystal structure of the trimeric N-terminal domain of ciliate Euplotes octocarinatus centrin binding with calcium ions. Protein Sci. 2018, 27, 1102-1108.

26 Zhigang Zhang, Yantao Zhu, Ruihui Dai, Yinghong Zhang, Hongfei Wang, Jiangang Li. Enhanced photocytotoxicity induced by a platinum diimine complex employing amine-functionalized magnetite-silica nanocomposites as delivery vehicles, Photodiagnosis Photodyn Ther. 2018, 23, 50-54.

27 Liqun Xu, Zhiou Ma, Wenming Wang, Leilei Xie, Lifang Liu, Jiao Liu, Xuan Zhao, Hongfei Wang. Photo-induced cytotoxicity, photo-controlled nitric oxide release and DNA/human serum albumin binding of three water-soluble nitrosylruthenium complexes, Polyhedron, 2017, 137, 157-164.

28 Xinyu Zhang, Wenming Wang, Chen Li, Yi Zhao, Hong Yuan, Xianshi Tan, Lijie Wu, Zhuanhua Wang, Hongfei Wang. Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity, J Inorg Biochem.2017, 173, 21-27.

29 Shengli Zhang, Jiachen Zang, Wenming Wang, Hai Chen, Xiaorong Zhang, Fudi Wang, Hongfei Wang, Guanghua Zhao. Conversion of Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues. Angew. Chem. Int. Ed. 2016, 55, 16064 -16070.

30 Tomonari Muramatsu, Chie Takemoto, Yong-Tae Kim, Hongfei Wang, Wataru Nishii, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama. SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity. Proc Natl Acad Sci USA. 2016, 113: 12997-13002.