张志刚, 男, 1968年9月生, 教授。1987年毕业于山西大学化学系，获得理学学士学位; 1990年于山西大学获得理学硕士学位; 1996 年毕业于南京大学无机化学专业，并获得理学博士学位。2000年12月至2002年12月于英国爱丁堡大学化学系做博士后研究工作。多年来一直从事金属基药物，尤其是金属基抗癌药物的合成及作用机理的研究，获得山西省科技进步理论二等奖一项。曾主持或参加过多项国家自然科学基金、山西省自然科学基金项目。

研究兴趣：

(1) 靶向抗肿瘤金属配合物光动力治疗剂的研究

(2) 磁性复合纳米粒子载药体系的研究

近年来发表的部分代表性论文：

1. "A valproic acid-modified platinum diimine complex as potential photosensitizer for photodynamic therapy", Zhifan Liu, Hongfei Wang, Zhigang Zhang*, J. Inorg. Biochem., 2021, 222: 111508.

2. "Triphenylphosphonium-functionalized nanocomposites as carriers of a platinum diimine complex for photodynamic therapy", Xue Bai, Yantao Zhu, Hongfei Wang, Jiangang Li, Zhigang Zhang*, Photodiagn. Photodyn. Ther., 2021, 34: 102223.

3. “Enhanced photocytotoxicity induced by a platinum diimine

complex employing amine-functionalized magnetite-silica nanocomposites as

delivery vehicles”, Zhigang Zhang*, Yantao Zhu, Ruihui Dai, Yinghong Zhang,

Hongfei Wang, Jiangang Li, Photodiagn. Photodyn. Ther., 2018, 23: 50-54.

4. “Photoactive platinum diimine complexes showing induced cancer cell death by apoptosis”, Zhigang Zhang*, Ruihui Dai, Biometals, 2017, 30(1): 37-42.

5. “Photoinduced cytotoxicity by a platinum diimine complex employing magnetite-silica nanocomposites as delivery vehicles”, Zhigang Zhang*, Haisha Li, Ruihui Dai, Aiyun Chai, Biometals, 2015, 28(5): 945-950.

6. “Photoinduced DNA damage and cytotoxicity by a triphenylamine-modified platinum-diimine complex”, Zhigang Zhang*, Ruihui Dai, Jiajia Ma, Shuying Wang, Xuehong Wei, Hongfei Wang, J. Inorg. Biochem., 2015, 143: 64-68.

7. “Core-shell magnetite-silica composite nanoparticles enhancing DNA damage induced by a photoactive platinum-diimine complex in red light”, Zhigang Zhang*, Aiyun Chai, J. Inorg. Biochem., 2012, 117: 71-76.

8. “Photodynamic activity of a nickel diimine complex and its interaction with DNA”, Zhigang Zhang*, Shuying Wang, Xindian Dong, Trans. Metal Chem.,

2012, 37(4): 379-383.

9. “Interaction of DNA with a novel photoactive platinum diimine complex” , Zhigang Zhang*, Xindian Dong, Biometals, 2009, 22(2): 283-288.

10. “Interaction of DNA with bis(diiminosuccinonitrilo)platinum(II)”, Zhigang Zhang*, Yuanyuan Sun, Xiaoming Jiang, , Chinese J. Chem., 2008, 26(3):

463-466.

联系方式

e-mail: zgzhang@sxu.edu.cn