姓名：张志刚
职称：教授
联系方式：zgzhang@sxu.edu.cn

介绍：
张志刚, 男, 1968年9月生, 教授。多年来一直从事金属基抗癌药物的合成及作用机理的研究，获得山西省科技进步理论二等奖一项。曾主持或参加过多项国家自然科学基金、山西省自然科学基金项目。

学习与工作经历：
2005.12 至今, 山西大学分子科学研究所, 教授
2000.12-2002.12 英国爱丁堡大学，博士后
1998.5-2005.12, 山西大学分子科学研究所, 副教授
1995.9-1998.5, 山西大学分子科学研究所, 讲师
1990.7起于山西大学分子科学研究所工作
1992.2-1996.3, 南京大学无机化学专业, 博士
1987.9-1990.7, 山西大学无机化学专业, 硕士
1983.9-1987.8, 山西大学化学专业, 学士

研究方向：
(1) 抗肿瘤金属配合物光动力治疗剂的研究
(2) 磁性复合纳米粒子载药体系的研究

讲授课程：

配位化学 （硕士生）

代表性论文：
(1). "Fluorescent superparamagnetic magnetite-silica nanocomposites as carriers of a platinum diimine complex for photodynamic therapy", Yuxin Lu, Xuemei Guo, Xin Wang, Xu Zhang, Hongfei Wang, Zhigang Zhang*, Biometals, 2025, 38: 285-295.

(2). "Enhanced photocytotoxicity induced by a triphenylphosphonium- appended platinum diimine complex"，Hongxia Qi, Xuemei Guo, Yuxin Lu, Chao Lan, Hongfei Wang, Zhigang Zhang*, J. Coord. Chem., 2024, 77(5-6): 577-587.

(3). "A valproic acid-modified platinum diimine complex as potential photosensitizer for photodynamic therapy", Zhifan Liu, Hongfei Wang, Zhigang Zhang*, J. Inorg. Biochem., 2021, 222: 111508.

(4). "Triphenylphosphonium-functionalized nanocomposites as carriers of a platinum diimine complex for photodynamic therapy", Xue Bai, Yantao Zhu, Hongfei Wang, Jiangang Li, Zhigang Zhang*, Photodiagn. Photodyn. Ther., 2021, 34: 102223.

(5). "Enhanced photocytotoxicity induced by a platinum diimine complex employing amine-functionalized magnetite-silica nanocomposites as delivery vehicles", Zhigang Zhang*, Yantao Zhu, Ruihui Dai, Yinghong Zhang, Hongfei Wang, Jiangang Li, Photodiagn. Photodyn. Ther., 2018, 23:50-54.

(6). “Photoactive platinum diimine complexes showing induced cancer cell death by apoptosis”, Zhigang Zhang*, Ruihui Dai, Biometals, 2017, 30(1): 37-42.

(7). “Photoinduced cytotoxicity by a platinum diimine complex employing magnetite-silica nanocomposites as delivery vehicles”, Zhigang Zhang*, Haisha Li, Ruihui Dai, Aiyun Chai, Biometals, 2015, 28(5): 945-950.

(8). “Photoinduced DNA damage and cytotoxicity by a triphenylamine-modified platinum-diimine complex”, Zhigang Zhang*, Ruihui Dai, Jiajia Ma, Shuying Wang, Xuehong Wei, Hongfei Wang, J. Inorg. Biochem., 2015, 143: 64-68.

(9). “Core-shell magnetite-silica composite nanoparticles enhancing DNA damage induced by a photoactive platinum-diimine complex in red light”, Zhigang Zhang*, Aiyun Chai, J. Inorg. Biochem., 2012, 117: 71-76.

(10). “Photodynamic activity of a nickel diimine complex and its interaction with DNA”, Zhigang Zhang*, Shuying Wang, Xindian Dong, Trans. Metal Chem., 2012, 37(4): 379-383.

(11). “Interaction of DNA with a novel photoactive platinum diimine complex” , Zhigang Zhang*, Xindian Dong, Biometals, 2009, 22(2): 283-288.

(12). “Interaction of DNA with bis(diiminosuccinonitrilo)platinum(II)”, Zhigang Zhang*, Yuanyuan Sun, Xiaoming Jiang, , Chinese J. Chem., 2008, 26(3):463-466.