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王宏飞
[ 发布日期:2019-01-09  ] 【返回

王宏飞1969年生,教授,博士生导师1996毕业于中国南京大学获得理学博士学位2001毕业于日本立教大学获得理学博士学位2001年至2003年,在日本理化学研究所基因科学研究中心从事博士后研究。2003年至2009年,在日本理化学研究所生命分子系统研究领域任特别研究员。2012年入选山西省引进海外高层次人才百人计划2013年入选山西省高等院131领军人才工程,2014年入选山西省学术技术带头人。2015年入选中国生物医学光子学专业委员会委员2018年入选中国生物物理化学专业委员会委员。

 

研究兴趣和领域:生物无机化学,生物物理化学

 

近期发表论文:

1  Selective Elimination of the Key Subunit Interfaces Facilitates Conversion of Native 24-mer Protein Nanocage into 8-mer Nanorings. J Am Chem Soc. 140, 14078–14081, 2018.

2 On-Axis Alignment of Protein Nanocage Assemblies from 2D to 3D through the Aromatic Stacking Interactions of Amino Acid Residues. ACS Nano 12, 11323–11332, 2018.

3   Crystal structure of the trimeric N-terminal domain of ciliate Euplotes octocarinatus centrin binding with calcium ions. Protein Sci. 27, 1102-1108, 2018.

4   Enhanced photocytotoxicity induced by a platinum diimine complex employing amine-functionalized magnetite-silica nanocomposites as delivery vehicles, Photodiagnosis Photodyn Ther. 23, 50-54, 2018.

5 Structures, Spectroscopic Properties, and Photodynamic Reactions of Three [RuCl(QN)NO]2 Complexes (HQN = 8-Hydroxyquinoline and Its Derivatives) as Potential NO-Donating Drugs. Bioinorg Chem Appl. doi: 10.1155/2018/7029376, 2018.

6 Design, Synthesis, And Preliminary Bioactivity Evaluation Of 2,7-Substituted Carbazole Derivatives As Potent Autotaxin Inhibitors And Antitumor Agents. Anticancer Agents Med Chem. doi: 10.2174/1871520618666180830161821, 2018.

7 Photo-induced cytotoxicity, photo-controlled nitric oxide release and DNA/human serum albumin binding of three water-soluble nitrosylruthenium complexes, Polyhedron, 137, 157–164, 2017.

8 Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity, J Inorg Biochem. 173, 21–27, 2017.

9  Conversion of Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues. Angew. Chem. Int. Ed. 55, 16064 -16070, 2016.

10  SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity. Proc Natl Acad Sci U. S. A. 113, 12997-13002, 2016.

11 Structures and spectroscopic properties of three [RuCl(2mqn)2NO] (H2mqn = 2-methyl-8-quinolinol) isomers: An experimental and density functional theoretical study, Polyhedron, 118, 61-69, 2016.

12 Differentiating Two Nitrosylruthenium Isomeric Complexes by Steady-State and Ultrafast Infrared Spectroscopies, J. Phys. Chem. B, 120, 11502-11509, 2016.

13 Structural dynamics of nitrosylruthenium isomeric complexes studied with steady-state and transient pump-probe infrared spectroscopies. Spectrochim Acta A Mol Biomol Spectrosc. 166, 62-67, 2016.

14 Structures and spectroscopic properties of three [Ru(OAc)(2mqn)2NO] (H2mqn = 2-methyl-8-quinolinol) isomers: An experimental and density functional theoretical insight. J Mol Struct. 1086, 232-238, 2015.

15 Photoinduced DNA damage and cytotoxicity by a triphenylamine-modified platinum-diimine complex. J Inorg Biochem. 143, 64-68, 2015.

16  Photo-controlled NO release from two nitrosylruthenium isomer complexes and their potential biomedical applications, J Biomed Opt. 20(1), 015004, 2015.

17 Photoisomerization and Structural Dynamics of Two Nitrosylruthenium Complexes: A Joint Study by NMR and Nonlinear IR Spectroscopies, Phys. Chem. Chem. Phys. 16, 24045-24054, 2014.

18 Structural, spectroscopic and functional investigation into Fe-substituted MnSOD from human pathogen Clostridium difficile, Metallomics, 6, 1540-1548, 2014.

19 Structural, electronic, vibrational and NMR spectral analyses of [Ru(OAc)(2cqn)2NO] (H2cqn=2-chloro-8-quinolinol) isomers, Spectrochim Acta A Mol Biomol Spectrosc. 122, 649–655, 2014.

20 Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile, Chem. Commun. 50, 584–586, 2014.

21 Binding of oxo-Cu2 clusters to ferric ion-binding protein A from Neisseria gonorrhoeae: a structural insight, Metallomics, 5, 1430–1439, 2013.

22 Ruthenium complexes as novel inhibitors of human islet amyloid polypeptide fibril formation. Metallomics, 5, 1599-1603, 2013.

23 A novel hydrogen peroxide sensor based on LaB6 electrode. Electrochimica Acta. 63, 64–68, 2012.

24  Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. Proc. Natl. Acad. Sci. U. S. A. 108, 7373–7378, 2011.

 

联系方式:
地址:太原市坞城路92
单位:山西大学分子科学研究所
邮编:030006
手机:158-3401-1037
E-mail: wanghf@sxu.edu.cn


友情链接: 北京大学 清华大学 南京大学 中科院山西煤化所 太原理工大学 中北大学
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