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卢丽萍
[ 发布日期:2012-12-05  ] 【返回

卢丽萍,理学博士, 教授,博士生导师。1963年6月生于湖南,湖南宁乡人。1983年6月本科毕业于湖南师范大学生物系生物学专业。1988年9月硕士研究生毕业于中国科学院昆明动物研究所细胞生物学专业。2003年7月博士研究生毕业山西大学生物无机化学专业。1998–1999年在英国爱丁堡大学细胞与分子生物学研究所进行果蝇突变型的分子与细胞生物学研究。2006-2007年在美国麻州大学化学与生物化学系合作研究。

主持国家自然科学基金,教育部留学回国人员科研启动基金项目,山西省自然科学基金,山西省回国留学人员科研项目等。

在Chem. Commun, J Biol Inorg Chem ,J. Inorg. Biochem.,Crystal Growth & Design,Anti-Cancer Agents Med. Chem.,Dalton Trans,Eur. J. Med. Chem., BioMetals, Inorg. Chim. Acta,Polyhedron Z. Anorg. Allg. Chem., Acta Cryst. C & E, J. Chem. Cryst.,《化学学报》、《化学进展》等国内外刊物发表论文80余篇。

目前主要研究方向: 金属离子及配合物与蛋白质相互作用及机理研究。

代表论文:

应邀综述

1. Liping Lu and Miaoli Zhu*, Metal-Based Inhibitors of Protein Tyrosine Phosphatases,Anti-Cancer Agents Med. Chem.,2011, 11, 164-171. (Invited Review)

研究论文

2. Caixia Yuan, Miaoli Zhu*, Qingming Wang, Liping Lu*, Shu Xing, Xueqi Fu*, Zheng Jiang, Shuo Zhang, Zongwei Li, Zhuoyu Li, Ruiting Zhu, Ling Ma, Liqing Xu, Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex, Chem. Commun., 2012, 48(8), 1153-1155.

3. Hong Han, Liping Lu*, Qingming Wang, Miaoli Zhu*, Caixia Yuan, Shu Xing*, Xueqi Fu, Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase1B, Dalton Trans., 2012,41(36), 11116-11124.

4. Liping Lu , Xiaoli Gao, Miaoli Zhu*, Sulian Wang, Qiong Wu, Shu Xing*, Xueqi Fu, Zhiwei Liu and Maolin Guo, Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases, BioMetals, 2012, 25, 599-610.

5. Qingming Wang, Miaoli Zhu*, Ruiting Zhu, Liping Lu*, Caixia Yuan, Shu Xing, Xueqi Fu*, Yuhua Mei, Exploration of α-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases, Eur. J. Med. Chem., 2012, 49, 354-364.

6. Qingming Wang, Miaoli Zhu*, Liping Lu*, Caixia Yuan, Shu Xing, Xueqi Fu, Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization, and biological activities, Dalton Trans., 2011, 40(48), 12926-12934.

7. Ling Ma, Liping Lu*, Miaoli Zhu, Qingming Wang, Ying Li, Shu Xing, Xueqi Fu, Zengqiang Gao, Yufei Dong, Mononuclear copper(II) complexes with 3,5-substituted-4- salicylideneamino-3,5- dimethyl-1,2,4-triazole: Synthesis, structure and potent inhibition of protein tyrosine phosphatases Dalton Trans., 2011, 40(24), 6532-6540.

8. Liping Lu, Jinjun Yue, Caixia Yuan, Miaoli Zhu*, Hong Han, Zhiwei Liu, Maolin Guo, Ternary oxovanadium(IV) complexes with amino acid-Schiff base and polypyridyl derivatives: Synthesis, characterization, and protein tyrosine phosphatase 1B inhibition, J. Inorg. Biochem., 2011, 105, 1323–1328.

9. Ling Ma, Liping Lu*, Miaoli Zhu, Qingming Wang, Fei Gao, Caixia Yuan, Yanbo Wu,Shu Xing, Xueqi Fu, Yuhua Mec, Xiaoli Gao, Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases J. Inorg. Biochem., 2011, 105, 1138–1147.

10. Ying Li, Liping Lu*, Miaoli Zhu, Qingming Wang, Caixia Yuan, Shu Xing, Xueqi Fu, Yuhua Mei, Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives BioMetals, 2011, 24, 993-1004.

11. Qingming Wang, Liping Lu,* Caixia Yuan, Kai Pei, Zhiwei Liu, Maolin Guo* and Miaoli Zhu*, Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: Implication to copper toxicity in biological systems, Chem. Commun., 2010, 46, 3547-3549.

12. Qi Ma, Miaoli Zhu*, Caixia Yuan, Sisi Feng, Liping Lu*, and Qingming Wang, A Molecular Helix: Self-Assembly of Coordination Polymers from d10 Metal Ions and 1,10-Phenanthroline-5,6-dione (pdon) with the Bridges of SCN- and Cl- Anions, Crystal Growth & Design, 2010, 10, 1706-1714.

13. Qi Ma, Miaoli Zhu*, Liping Lu*, Sisi Feng, Tianwei Wang, Synthesis and characterisation of Mn(II), Co(II) and Cd(II) coordination polymers of 1,2,4-triazole-3, 5-dicarboxylic acid, Dalton Trans. 2010, 39, 5877-5884.

14. Caixia Yuan, Liping Lu*, Xiaoli Gao, Yanbo Wu, Maolin Guo, Ying Li, Xueqi Fu, Miaoli ZhuTernary oxovanadium(IV) complexes of ONO donor Schiff base and polypyridyl derivatives as protein tyrosine phosphatase inhibitors: synthesis, characterization and biological activitie, J Biol Inorg Chem 2009, 14(6),841-851.

15. Sisi Feng, Miaoli Zhu*, Liping Lu, Lei Du, Yunbo Zhang and Tianwei Wang, Rationally Designed Chiral Ni5L6 Clusters with the in Situ Generated Tridentate Ligand. Hydrothermal Synthesis, Crystal Structures, Morphology and Magnetic Properties, Dalton Trans. 2009, (32), 6385-6395.

16. Sisi Feng, Miaoli Zhu, Liping Lu and Maolin Guo,Single-crystal metal–organic microtubes self-assembled from designed D3 symmetrical nanoclusters with a capped triple-helix pentanuclear M5O6 core, Chem. Commun., 2007, (45) 4785–4787. ( highlighted by NatureCHINA Doi:10.1038/nchina.2007.202) http://www.nature.com/nchina/2007/071003/full/nchina.2007.202.html .

17. Liping Lu, Miaoli Zhu, Pin Yang*, Crystal structure and nuclease activity of mono(1, 10-phenanthroline)copper complex, J Inorg. Biochem., 2003, 95(1), 31-36.

 

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地址:太原市坞城路92号
单位:山西大学分子科学研究所
邮编:030006
办公电话:0351-7018755
eMail: luliping@sxu.edu.cn

 

 


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