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赵亚琴
[ 发布日期:2019-01-09  ] 【返回

赵亚琴 ,女,1977年出生,硕士生导师。2004年获理学硕士, 2008年获理学博士,2010.2~2012.2山西大学生物学博士后,2005至今,在山西大学分子科学研究所工作。主要从事生物无机化学、分子生物学等方面的研究。作为主要成员先后参与国家自然科学基金面上项目、省部级项目多项,目前主持国家自然科学青年基金一项(No. 20901048),主持山西省自然科学青年基金一项(No.2011021006-1)

 

研究方向:

①功能配合物对蛋白质结构的影响及功能调控。

②磷酸化、泛素化等蛋白质修饰参与的信号转导研究

 

论文:

1. Zhao YaqinCui XiaofangBinsheng Yang. Conformational discrimination of three human centrins. RSC Adv2017744348-44355.(二区)

Molecular simulation structure of EoCen using Swiss-model software.

2. Zhao YaqinGuo XiaojuanBinsheng YangRegulation of centrin self-assembly investigated by fluorescence resonance light scattering. RSC Adv20177,10206-10214. (二区)

zyq1.png

AFM image of PKA phosphorylated EoCen.

 

3. Zhao YaqinChu XuefengBinsheng YangElectrochemical behavior of hemin binding with human centrin 3, Bioelectrochemistry, 2017, 117, 15-22. (二区)

Cyclic voltammograms of hemin (100 μM) in the absence (a) or presence (b) of apoHsCen3 (A) or holoHsCen3 (B) in PBS buffer at pH 7.4.

4. Zhao Yaqin; Xu Qiming; Xu Wei; Wang Dangdang; Jason Tan; Zhu Cuiqing; Tan Xiangshi, Probing the molecular mechanism of ceriumoxide nanoparticles in protecting against the neuronal cytotoxicity of Aβ1-42 with copper ions, Metallomics, 2016.7.8, 8: 644~647.

Detection of Ab1-42 aggregation in living cells using [Ru(phen)2dppz]2+ (0.5 μM) (red) by confocal scanning laser microscopy imaging. SH-SY5Y cells were stained with DAPI for visualizing nucleus (blue). SH-SY5Y cells (A), were treated with Ab1-42 (20 μM) (B), Cu2+-Ab1-42 (20 μM) (C), Cu2+-Ab1-42 (20 μM) plus CeONP (50 μM)  (D) after incubation for 4h, respectively.

 

5. Zhao YaqinCui Xiaofang, Yang Jing, Yu Lu, Binsheng YangElectrochemical characterization of Fe center from hemin binding with Yersinia pestis heme-protein acquisition system, Electrochimica Acta, 2019, 298, 518-524.

EIS of hemin (65 μM) in the absence (b) or presence of different concentrations of YpHmuT (c: [YpHmuT] = 70 μM, d: [YpHmuT] = 35 μM) in PBS buffer (a). The frequency range was in 0.01105 Hz at 0.15 V. The inset shows the equivalent circuit used to model impedance data.

 

6. Wang Wenming, Zhao Yaqin, Wang Hongfei, Yang Binsheng, Crystal structure of the trimeric N-terminal domain of ciliate Euplotes octocarinatus centrin binding with calcium ions, Protein Science, 2018, 27, 1102-1108.

(A) X-ray of N-EoCen from the front (left) and the back (right). N-ter, N terminal end; C-ter, C-terminal end. Two Ca2+ ion binding sites are indicated. (B) The triangle trimer of N-EoCen is shown as a ribbon and electron potential surface representation from front view, side view, and back view. Positive regions are blue, negative regions are red, and neutral regions are shown in white.

 

基金:

山西省自然科学基金:鼠疫耶尔森菌YpHmuT蛋白介导的铁调控吸收机理的研究(201801D121198)

 

联系方式

地址:太原市坞城路92号

单位:山西大学分子科学研究所

邮编:030006

e-mail:zhaoyaqin@sxu.edu.cn

 

 


友情链接: 北京大学 清华大学 南京大学 中科院山西煤化所 太原理工大学 中北大学
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