首   页   
   研究所简介  
   机构设置  
   研究人员  
   学科建设  
   科研动态  
   研究成果  
   在研项目  
   博士后流动站  
   办事流程  
   网上下载  
   图书仪器  
   学术交流  
   廿年回眸  
   教师招聘  
   特色资源  
 
 
您现在的位置: 首页» 研究人员
 
 
袁彩霞
[ 发布日期:2017-02-21  ] 【返回

袁彩霞,女,1979年生,理学博士,副教授,硕士生导师。2001年毕业于山西大学化学系,获理学学士学位,2004年获山西大学理学硕士学位,并留校工作,2009年获山西大学理学博士学位,博士毕业论文荣获2009年度山西省优秀论文,2014年获国家留学基金委资助赴美国科罗拉多大学访学一年。目前在国内外学术期刊发表SCI论文40多篇,获得授权专利3项,以第四完成人获山西省科学技术奖自然科学二等奖1项。主持国家自然科学基金面上项目、青年基金和山西省青年科学基金各一项,参与国家自然科学基金、山西省青年科技基金以及归国留学基金等项目多项。

研究工作:
主要从事配位化学、生物无机化学和主族金属结构化学的研究。目前研究方向包括:

  1. 过渡金属配合物的合成、表征、及其与蛋白质相互作用机理研究;
  2. 有机或金属有机分子对过渡金属的荧光识别研究;
  3. 多原子分子中主族金属的成键特性研究。

主持项目:
1、国家自然科学基金面上项目,肝再生磷酸酶-3和法尼基酶双靶点锌配合物抑制剂的设计、合成及抗肿瘤活性研究(No.21471092),2015/01-2018/12,85万元。
2、国家自然科学基金青年基金项项目,靶向蛋白酪氨酸磷酸酶抗肿瘤铂配合物的设计、合成及作用机理研究(No.21001070),2011/01-2013/12,19万元。
3、山西省自然基金项目, 靶向蛋白酪氨酸磷酸酶抗肿瘤铂配合物的设计、合成及活性研究(No. 2011021006-2),2011/01-2013/12,4万元。

近期主要研究论文:

  1. Caixia Yuan, Shiyang Li, Yanbo Wu, Liping Lu, Miaoli Zhu, Zn(II)-selective and sensitive fluorescent chemosensor based on stericconstrains and inhibition of ESIPT, Sensors and Actuators B. 2017, 242, 1035–1042.
  2. Yuqi Jia, Liping Lu, Miaoli Zhu, Caixia Yuan, Shu Xing, Xueqi Fu, A dioxidovanadium (V) complex of NNO-donor Schiff base as a selective inhibitor of protein tyrosine phosphatase 1B: Synthesis, characterization, and biological activities, Eur. J. Med. Chem. 2017, 28, 287-292.
  3. Yuqi Jia, Liping Lu, Caixia Yuan, Sisi Feng, Miaoli Zhu, Aspartate aminotransferase is potently inhibited by copper complexes: Exploring copper complex-binding proteome, J. Inorg. Biochem. 2017, 170, 46–54.
  4. LI Yan-Hong, LU Li-Ping, ZHU Miao-Li, YUAN Cai-Xia, FENG Si-Si, GAO Zeng-Qiang, Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine, Chinese J. Struct. Chem. 2017, 36(2), 316-323.
  5. Jia-Jia Li, Yuewen Mu, Xinxin Tian, Caixia Yuan, Yan-Bo Wu, Qiang Wang, Debao Li, Zhi-Xiang Wang and Si-Dian Li, Zigzag double-chain C–Be nanoribbon featuring planar pentacoordinate carbons and ribbon aromaticity, J. Mater. Chem. C 2017, 5, 408-414.
  6. Caixia Yuan, Xinyu Liu, YanboWu, Liping Lu , Miaoli Zhu, A triazole Schiff base-based selective and sensitive fluorescent probe for Zn2+: A combined experimental and theoretical study, Spectrochim. Acta A, 2016, 154, 215–219.
  7. Caixia Yuan, Xue-Feng Zhao, Yan-Bo Wu, Xiaotai Wang, Ultrashort Beryllium-Beryllium Distances Rivalling Those of Metal-Metal Quintuple Bonds Between Transition Metals, Angew. Chem. Int. Ed. 2016, 55, 15651-15655.
  8. Caixia Yuan, Yan-BoWu, Xiaotai Wang, N-heterocyclic carbene-stabilized homoatomic lithium(0) complexes with a lithium–lithium covalent bond: A theoretical design and characterization, Inorg. Chem. Commun. 2016, 63, 61–64.
  9. LI Yan-Hong, LU Li-Ping, ZHU Miao-Li, YUAN Cai-Xia, FENG Si-Si, GAO Zeng-Qiang, A Copper(II) Complex Based on N-(4-hydroxybenzyl)-L-serine: Synthesis, Crystal Structure and Inhibitory Activity on PTP1B and TCPTP, Chinese J. Struct. Chem. 2016, 35(11),1686-1693.
  10. 李艳红, 袁彩霞, 卢丽萍, 朱苗力, 付学奇, 邢 述, 高增强, N?(2?吡啶甲基) ?L?丝氨酸铜配合物的合成、晶体结构及抑制蛋白酪氨酸磷酸酶活性, 高等学校化学学报, 2016, 37(12), 2138-2143.
  11. Xiang Wang, Qiang Wang, Caixia Yuan, Xue-Feng Zhao, Jia-Jia Li, Debao Li, Yan-Bo Wu, Xiaotai Wang, The degree of p electron delocalization and the formation of 3D-extensible sandwich structures, Phys. Chem. Chem. Phys. 2016, 18, 11942-11950.
  12. Xue-Feng Zhao, Haixia Li, Cai-Xia Yuan, Yan-Qin Li, Yan-Bo Wu, Zhi-Xiang Wang, Linear, Planar, and Tubular Molecular Structures Constructed by Double Planar Tetracoordinate Carbon D2h C2(BeH)4 Species via Hydrogen-Bridged -BeH2Be- Bonds, J. Comput. Chem. 2016, 37, 261-269.
  13. Xue-Feng Zhao, Cai-Xia Yuan, Xiang Wang, Jia-Jia Li, Yan-Bo Wu, Xiaotai Wang, Computational Desian of Organometallic Oligomers Featuring 1,3-Metal-Carbon Bonding and Planar Tetracoordinate Carbon Atoms, J. Comput. Chem. 2016, 37, 296-303.
  14. 袁彩霞,兰淑芬,卢丽萍,水杨醛缩芳胺席夫碱铜(II)配合物抑制蛋白酪氨酸磷酸酶活性研究,无机化学学报2015, 31(5), 915-922.
  15. Liu, Qiaoling ; Feng, Lixia; Yuan, Caixia; Zhang, Lin; Shuang, Shaomin; Dong, Chuan; Hu, Qin; Choi, Martin M. F., A highly selective fluorescent probe for cadmium ions in aqueous solution and living cells, Chem. Commun., 2014, 50(19), 2498-2501
  16. Ruiting Zhu, Liping Lu, Miaoli Zhu, Hong Han, Caixia Yuan, Shu Xing, Xueqi Fu, Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxy- benzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases, Inorg. Chim. Acta, 2013, 405, 91–97.
  17. Caixia Yuan, Miaoli Zhu, Qingming Wang,et.al., Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex, Chem. Commun., 2012, 48, 1153–1155.
  18. Caixia Yuan, Liping Lu, Yanbo Wu, et.al., Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives, J. Inorg. Biochem., 2010, 104, 978-986.
  19. Caixia Yuan, Liping Lu, Xiaoli Gao,et.al., Ternary oxovanadium(IV) complexes of ONO-donor Schiff base and polypyridyl derivatives as protein tyrosine phosphatase inhibitors: synthesis, characterization, and biological activities. J. Biol. Inorg. Chem. 2009, 14, 841-851.

授权专利:

  1. 袁彩霞,吴艳波,朱苗力,卢丽萍,一种氨基萘酚类席夫碱化合物及其制备方法和应用,专利号,ZL201310164901.X。
  2. 袁彩霞, 朱苗力,卢丽萍,一种双核铂(II)配合物及其制备方法和应用,专利号,ZL201310385189.6。
  3. 袁彩霞, 朱苗力, 卢丽萍, 一种氧钒配合物及其制备方法和应用,专利号, CN2013101656278

欢迎热爱科学研究,有志于科学事业的同学报考本课题组的研究生。

联系方式:
地址:太原市坞城路92号
单位:山西大学分子科学研究所
邮编:030006
手机:13513634694
电子邮箱:cxyuan@sxu.edu.cn


友情链接: 北京大学 清华大学 南京大学 中科院山西煤化所 太原理工大学 中北大学
版权所有©山西大学分子科学研究所