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朱苗力
[ 发布日期:2012-12-05  ] 【返回

朱苗力,理学博士,教授,博士生导师,山西省研究生教育优秀导师(2011年),山西省优秀博士论文导师(2008、2009、2010年度)。1957年3月生于湖南,湖南洞口人;中共党员,中国化学会永久会员。1981年12月本科毕业于湖南师范大学化学系、1988年7月和2003年7月无机化学硕、博士研究生毕业于山西大学分子科学研究所。获国家留学基金分别于1998年赴英国爱丁堡大学化学系访问研究一年、2007年赴美国麻州大学化学与生物化学系合作研究半年。

主要从事结构化学、配位化学和生物无机化学研究。目前研究方向:1、配合物与蛋白质相互作用研究(包括配合物合成、与蛋白质相互作用、生物大分子晶体结构等);2、手性配位聚合物构筑、晶体结构、性质及机理研究。

主持国家自然科学基金项目(20471033,2005–2007年;21271121,2013–2016年)、高等学校博士学科点专项科研基金(博导类,20111401110002,2012–2014年)、山西省自然科学基金项目(20051013,2005–2007年;2010011011-2,2010–2012年)、山西省回国留学人员科研项目(2003–2005年,2006-2008年)、南京大学配位化学国家重点实验室开放课题、北京同步辐射、上海光源国家实验室课题。

取得研究成果:国家专利两项、科技成果鉴定一项、出版教材两本;在Chem. Commun,Crystal Growth & Design,CrystEngComm,Dalton Trans,J. Biol. Inorg. Chem.,J. Inorg. Biochem.,Anti-Cancer Agents Med. Chem.,Eur. J. Med. Chem., BioMetals, Inorg. Chim. Acta,Polyhedron, Z. Anorg. Allg. Chem., Acta Cryst. C & E, J. Chem. Cryst.,《化学学报》、《结构化学》等学术期刊发表论文120余篇。

代表论文:

应邀综述

1. Liping Lu and Miaoli Zhu*, Metal-Based Inhibitors of Protein Tyrosine Phosphatases,Anti-Cancer Agents Med. Chem.,2011, 11, 164-171. (Invited Review)

研究论文

2. Caixia Yuan, Miaoli Zhu*, Qingming Wang, Liping Lu*, Shu Xing, Xueqi Fu*, Zheng Jiang, Shuo Zhang, Zongwei Li, Zhuoyu Li, Ruiting Zhu, Ling Ma, Liqing Xu, Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex, Chem. Commun., 2012, 48(8), 1153 – 1155.

3. Sisi Feng, Haigang Lv, Zhongping Li, Guoqin Feng, Liping Lu* and Miaoli Zhu*, The first example of rhombic dodecahedral CuBr clusters in a novel mixed-valence Cu(I,II)- benzimidazole complex, CrystEngComm, 2012, 14, 98-102.

4. Hong Han, Liping Lu*, Qingming Wang, Miaoli Zhu*, Caixia Yuan, Shu Xing*, Xueqi Fu, Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase1B, Dalton Trans., 2012,41(36), 11116-11124. 

5. Qingming Wang, Miaoli Zhu*, Ruiting Zhu, Liping Lu*, Caixia Yuan, Shu Xing, Xueqi Fu*, Yuhua Mei, Exploration of α-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases, Eur. J. Med. Chem., 2012, 49, 354-364.

6. Liping Lu , Xiaoli Gao, Miaoli Zhu*, Sulian Wang, Qiong Wu, Shu Xing*, Xueqi Fu, Zhiwei Liu and Maolin Guo, Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases, BioMetals, 2012, 25, 599-610.

7. Weiwei Jia, Junhua Luo, Miaoli Zhu*, A Molecular Basketwork: Self-Assembly of Coordination Polymers from Zn(II) and Biphenyl-3,4'- dicarboxylate Regulated by Different Flexible Bridging & Chelating N-Donor Ancillary Ligands, Crystal Growth & Design, 2011, 11, 2386-2397.

8. Qingming Wang, Miaoli Zhu*, Liping Lu*, Caixia Yuan, Shu Xing, Xueqi Fu, Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization, and biological activities, Dalton Trans., 2011, 40(48), 12926-12934.

9. Ling Ma, Liping Lu*, Miaoli Zhu, Qingming Wang, Ying Li, Shu Xing, Xueqi Fu, Zengqiang Gao, Yufei Dong, Mononuclear copper(II) complexes with 3,5-substituted-4- salicylideneamino-3,5- dimethyl-1,2,4-triazole: Synthesis, structure and potent inhibition of protein tyrosine phosphatases Dalton Trans., 2011, 40(24), 6532 – 6540.

10. Liping Lu, Jinjun Yue, Caixia Yuan, Miaoli Zhu*, Hong Han, Zhiwei Liu, Maolin Guo, Ternary oxovanadium(IV) complexes with amino acid-Schiff base and polypyridyl derivatives: Synthesis, characterization, and protein tyrosine phosphatase 1B inhibition, J. Inorg. Biochem., 2011, 105, 1323–1328.

11. Ling Ma, Liping Lu*, Miaoli Zhu, Qingming Wang, Fei Gao, Caixia Yuan, Yanbo Wu,Shu Xing, Xueqi Fu, Yuhua Mec, Xiaoli Gao, Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases J. Inorg. Biochem., 2011, 105, 1138–1147.

12. Ying Li, Liping Lu*, Miaoli Zhu, Qingming Wang, Caixia Yuan, Shu Xing, Xueqi Fu, Yuhua Mei, Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives BioMetals, 2011, 24, 993 - 1004.

13. Qingming Wang, Liping Lu,* Caixia Yuan, Kai Pei, Zhiwei Liu, Maolin Guo* and Miaoli Zhu*, Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: Implication to copper toxicity in biological systems, Chem. Commun., 2010, 46, 3547-3549.

14. Huili Chen, Wei Gao, Miaoli Zhu, Hongfei Gao, Jinfang Xue and Yingqi Li, A highly selective OFF–ON fluorescent sensor for zinc in aqueous solution and living cells, Chem. Commun., 2010, 46, 8389-8391.

15. Qi Ma, Miaoli Zhu*, Caixia Yuan, Sisi Feng, Liping Lu*, and Qingming Wang, A Molecular Helix: Self-Assembly of Coordination Polymers from d10 Metal Ions and 1,10-Phenanthroline-5,6-dione (pdon) with the Bridges of SCN- and Cl- Anions, Crystal Growth & Design, 2010, 10, 1706-1714.

16. Qi Ma, Miaoli Zhu*, Liping Lu*, Sisi Feng, Tianwei Wang, Synthesis and characterisation of Mn(II), Co(II) and Cd(II) coordination polymers of 1,2,4-triazole-3, 5-dicarboxylic acid, Dalton Trans. 2010, 39, 5877-5884.

17. Caixia Yuan, Liping Lu*, Xiaoli Gao, Yanbo Wu, Maolin Guo, Ying Li, Xueqi Fu, Miaoli ZhuTernary oxovanadium(IV) complexes of ONO donor Schiff base and polypyridyl derivatives as protein tyrosine phosphatase inhibitors: synthesis, characterization and biological activitie, J Biol Inorg Chem 2009, 14(6),841-851.

18. Sisi Feng, Miaoli Zhu*, Liping Lu, Lei Du, Yunbo Zhang and Tianwei Wang, Rationally Designed Chiral Ni5L6 Clusters with the in Situ Generated Tridentate Ligand. Hydrothermal Synthesis, Crystal Structures, Morphology and Magnetic Properties, Dalton Trans. 2009, (32), 6385-6395.

19. Sisi Feng, Miaoli Zhu, Liping Lu and Maolin Guo,Single-crystal metal–organic microtubes self-assembled from designed D3 symmetrical nanoclusters with a capped triple-helix pentanuclear M5O6 core, Chem. Commun., 2007, (45) 4785–4787. ( highlighted by NatureCHINA Doi:10.1038/nchina.2007.202)

http://www.nature.com/nchina/2007/071003/full/nchina.2007.202.html.

联系方式:

地址:太原市坞城路92号
单位:山西大学分子科学研究所
邮编:030006
电话:0351-7017974
eMail: miaoli@sxu.edu.cn

 


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