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魏春英
[ 发布日期:2017-01-23  ] 【返回

魏春英 女,1970年6月出生。博士,教授,博士生导师。1993年毕业于山西大学化学系,获理学学士学位,1996年获山西大学理学硕士学位,2002年获山西大学理学博士学位。曾在日本Konan University(2003.4-2004.3)和中国科学院大连化学物理研究所(2004.9-2006.12)做博士后研究。在国内外重要期刊发表SCI收录论文50余篇,论文被引用600余次。授权中国发明专利2项,获山西省科技进步二等奖1项。作为项目负责人主持并完成多项国家和省部级自然科学基金项目,研究方向为化学生物学,目前的主要研究兴趣为:(1)荧光贵金属纳米簇的制备及生物化学传感;(2) 核酸探针分子的设计、合成和应用;(3) 基于G-四链体 DNA靶标的抗癌药物的设计、合成,生物活性及分子机制研究。

近五年代表性论文: 
1. Dan Han, Chunying Wei*,A molecular beacon based on DNA-templated silver  nanoclusters for the highly sensitive and selective multiplexed detection of virulence genes, Talanta, 2018, 181, 24–31.
2. Guoyan Hao, Jinyu Sun, Chunying Wei*, Studies on interactions of carbazole derivatives with DNA, cell image,and cytotoxicity, Bioorganic & Medicinal Chemistry, 2018, 26, 285–294.
3. Baozhu Zhang and Chunying Wei*, Highly sensitive and selective fluorescence detection of Hg2+ based on turn-on aptamer DNA silver nanoclusters, RSC Adv., 2017, 7, 56289.
4. Baozhu Zhang and Chunying Wei* A Label-free fluorescent sensor based on structure-switching oligonucleotides for the detection of Ag+, biothiols and acetylcholinesterase activity, ChemistrySelect, 2017, 2, 6844-6849. 
5. Jiaona Xu, Chunying Wei*, The aptamer DNA-templated fluorescence silver nanoclusters: ATP detection and preliminary mechanism investigation, Biosensors and Bioelectronics, 2017, 87, 422-427.
6. Chunying Li, Chunying Wei*, DNA-functionalized silver nanoclusters as label-free fluorescent probe for the highly sensitive detection of biothiols and acetylcholinesterase activity, Sensors and Actuators B: Chemical, 2017, 240, 451-458.
7. Chunying Li, Chunying Wei*, DNA-templated silver nanocluster as a label-free fluorescent probe for the highly sensitive and selective detection of mercury ions, Sensors and Actuators B: Chemical, 2017, 242, 563-568.
8. Jiaona Xu and Chunying Wei*, A novel, label-free fluorescence detection method for the formation of G-quadruplex DNA based on DNA-templated silver nanoclusters, RSC Adv., 2017, 7, 24628
9. Chunying Wei*, Ning Gao, Cytotoxicities, Telomerase and Topoisomerases I Inhibitory Activities and Interactions of Terpyridine Derivatives with DNAs, Chem. Res. Chin. Univ., 2015, 31(6), 970-975.
10. Huiqing Li, Chunying Wei*, Mechanism studies on anti-HepG2 cell proliferation of phenanthroline derivatives as G-quadruplex DNA stabilizers, Bioorg. Med. Chem. Lett., 2015, 25(18), 3798-3803.
11. Ning Gao, Yanbo Wang, Chunying Wei*, Interactions of phenanthroline compounds with i-motif DNA, Chem. Res. Chin. Univ., 2014, 30(3), 495-499.
12. Lihua Wang, Yanbo Wu, Tinggui Chen, Chunying Wei*, The interactions of phenanthroline compounds with DNAs: Preferential binding to telomeric quadruplex over duplex, Int. J. Biol. Macromol., 2013,52 (1), 1– 8. 
13. Lihua Wang, Chunying Wei*, Spectroscopic and biological studies of phenanthroline compounds: selectively recognize gene promoter G-quadruplex DNAs over duplex DNA, Chem. Biodivers., 2013, 10(6),963. 
14. Chun-Ying Wei*, Jun-Hong Wang, Ye Wen, Jie Liu, Li-Hua Wang,4-(1H-Imidazo[4,5-f]-1,10-phenanthrolin-2-yl) phenol-based G-quadruplex DNA binding agents: telomerase inhibition, cytotoxicity and DNA-binding studies, Bioorg. Med. Chem. 2013, 21(11), 3379-3387. 
15. Chunying Wei*, Lijun Ren, Ning Gao, Interaction of terpyridine and their Pt(II) complexes with G-quadruplex DNAs and telomerase inhibition, Int. J. Biol. Macromol., 2013, 55 (6), 185–192. 
16. Chunying Wei*, Ye Wen, Junhong Wang, Novel platinum complexes as efficient G-quadruplex DNA binders and telomerase inhibitors, Int. J. Biol. Macromol., 2013, 55(4), 185–192. 
17. Chunying Wei,* Yanbo Wang and Meiying Zhang,Synthesis and binding studies of novel di-substituted phenanthroline compounds with genomic promoter and human telomeric DNA G-quadruplexes,Org. Biomol. Chem., 2013, 11(14), 2355–2364。 

授权专利:
1. 魏春英, 王俊虹, 刘洁, 一种咪唑[4,5-f]并1,10-邻菲罗啉衍生物及其制备方法和用途,ZL 2011 1 0143258.3.
2. 魏春英, 高宁,一种香豆素衍生物及其制备方法和用途, ZL 2013 1 0185722.4.

主持科研项目: 
1. 国家自然科学基金4项(21171108,21041008,20503029,20673110); 
2. 教育部博士学科点专项基金(博导类)1项(2010); 
3. 山西省自然科学基金3项(20041032,2009011012-2,201601D011026); 
4. 山西省留学回国人员基金2项(2011-016,2007);
5. 山西省回国留学择优资助项目1项(2009); 
6. 中国科学院王宽诚博士后工作奖励基金(2005); 
7. 山西省科研单位科研设备购置专项1项(2016)。

人才项目:
2014年度山西省高校131人才项目1项

获奖:
《研究稀土跨膜新方法的建立及其应用》 杨 频  魏春英  韦天新  王海燕  陈 榕,2003年山西省科技进步二等奖。


联系方式: 
地址:  太原市坞城路92号 
单位:  山西大学分子科学研究所 
邮编:  030006 
Tel:     13935182131
E-mail:  weichuny@sxu.edu.cn 


友情链接: 北京大学 清华大学 南京大学 中科院山西煤化所 太原理工大学 中北大学
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