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[ 发布日期:2019-01-10 ] 【返回】 |
魏春英 女,1970年6月出生。博士,教授,博士生导师。1993年毕业于山西大学化学系,获理学学士学位,1996年获山西大学理学硕士学位,2002年获山西大学理学博士学位。曾在日本Konan University(2003.4-2004.3)和中国科学院大连化学物理研究所(2004.9-2006.12)做博士后研究。在国内外重要期刊发表SCI收录论文50余篇。授权中国发明专利2项,获山西省科技进步二等奖1项。作为项目负责人主持并完成多项国家和省部级自然科学基金项目,研究方向为化学生物学,目前的研究兴趣为:(1)荧光贵金属纳米簇的制备及生物化学传感;(2) 核酸探针分子的设计、合成和应用;(3) 基于G-四链体 DNA靶标的抗癌药物的设计、合成,生物活性及分子机制研究。
近三年发表的代表性论文:
Anqi Mao and Chunying Wei*, Cytosine-rich ssDNA-templated fluorescent silver and copper/silver nanoclusters: optical properties and sensitive detection for mercury(II), Microchimica Acta, 2019, 186, 541.
Dan Han and Chunying Wei*,Nucleic acid probe based on DNA-templated silver nanoclusters for turn-on fluorescence detection of tumor suppressor gene p53,RSC Adv., 2018, 8, 25611.
Bin Wang and ChunYing Wei*,Stimuli-responsive fluorescence switching of cyanostilbene derivatives: ultrasensitive water, acidochromism and mechanochromism,RSC Adv., 2018, 8, 22806.
Baozhu Zhang and Chunying Wei*,Highly sensitive and selective detection of Pb2+ using a turn-on fluorescent aptamer DNA silver nanoclusters sensor, Talanta, 2018, 182, 125–130.
Dan Han, Chunying Wei*,A molecular beacon based on DNA-templated silver nanoclusters for the highly sensitive and selective multiplexed detection of virulence genes, Talanta, 2018, 181, 24–31.
Guoyan Hao, Jinyu Sun, Chunying Wei*, Studies on interactions of carbazole derivatives with DNA, cell image,and cytotoxicity, Bioorganic & Medicinal Chemistry, 2018, 26, 285–294.
Baozhu Zhang and Chunying Wei*, Highly sensitive and selective fluorescence detection of Hg2+ based on turn-on aptamer DNA silver nanoclusters, RSC Adv., 2017, 7, 56289.
Baozhu Zhang and Chunying Wei* A Label-free fluorescent sensor based on structure-switching oligonucleotides for the detection of Ag+, biothiols and acetylcholinesterase activity, ChemistrySelect, 2017, 2, 6844-6849.
Jiaona Xu, Chunying Wei*, The aptamer DNA-templated fluorescence silver nanoclusters: ATP detection and preliminary mechanism investigation, Biosensors and Bioelectronics, 2017, 87, 422-427.
Chunying Li, Chunying Wei*, DNA-functionalized silver nanoclusters as label-free fluorescent probe for the highly sensitive detection of biothiols and acetylcholinesterase activity, Sensors and Actuators B: Chemical, 2017, 240, 451-458.
Chunying Li, Chunying Wei*, DNA-templated silver nanocluster as a label-freefluorescent probe for the highly sensitive and selective detection of mercury ions, Sensors and Actuators B: Chemical, 2017, 242, 563-568.
Jiaona Xu and Chunying Wei*, A novel, label-free fluorescence detection method for the formation of G-quadruplex DNA based on DNA-templated silver nanoclusters, RSC Adv., 2017, 7, 24628.
授权专利:
1. 魏春英, 王俊虹, 刘洁, 一种咪唑[4,5-f]并1,10-邻菲罗啉衍生物及其制备方法和用途,ZL 2011 1 0143258.3.
2. 魏春英, 高宁,一种香豆素衍生物及其制备方法和用途, ZL 2013 1 0185722.4.
主持科研项目:
1. 国家自然科学基金4项(21171108,21041008,20503029,20673110);
2. 教育部博士学科点专项基金(博导类)1项(2010);
3. 山西省自然科学基金3项(20041032,2009011012-2,201601D011026);
4. 山西省留学回国人员基金2项(2011-016,2007);
5. 山西省回国留学择优资助项目1项(2009);
6. 中国科学院王宽诚博士后工作奖励基金(2005);
7. 山西省科研单位科研设备购置专项1项(2016)。
人才项目:
2014年度山西省高校131人才项目1项
获奖:
《研究稀土跨膜新方法的建立及其应用》 杨 频 魏春英 韦天新 王海燕 陈 榕,2003年山西省科技进步二等奖。
联系方式: 地址: 太原市坞城路92号 单位: 山西大学分子科学研究所 邮编: 030006 Tel: 13935182131 E-mail: weichuny@sxu.edu.cn
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